diff --git a/python/screen_grab/screen_grab.py b/python/screen_grab/screen_grab.py
index 2ff75f15..325c9b25 100644
--- a/python/screen_grab/screen_grab.py
+++ b/python/screen_grab/screen_grab.py
@@ -15,6 +15,8 @@
 from sgtk.platform.qt import QtCore, QtGui
 import sgtk
 
+QT_MAJOR = int(QtCore.qVersion().split(".")[0])  # Works for PySide* and PyQt*
+
 
 class ScreenGrabber(QtGui.QDialog):
     """
@@ -332,10 +334,26 @@ def get_desktop_pixmap(rect):
     :returns: Captured image
     :rtype: :class:`~PySide.QtGui.QPixmap`
     """
-    desktop = QtGui.QApplication.desktop()
-    return QtGui.QPixmap.grabWindow(
-        desktop.winId(), rect.x(), rect.y(), rect.width(), rect.height()
-    )
+    desktop_id = QtGui.QApplication.desktop().winId()
+    x_y_w_h = rect.x(), rect.y(), rect.width(), rect.height()
+
+    if QT_MAJOR == 5:
+        screen = QtGui.QApplication.primaryScreen()
+        try:
+            pixmap = screen.grabWindow(desktop_id, *x_y_w_h)
+        except TypeError as error:
+            if "quintptr" in str(error):
+                ptr_type = getattr(__builtins__, "long", int)  # Py3 safe long
+                pixmap = screen.grabWindow(ptr_type(desktop_id), *x_y_w_h)
+            else:
+                raise
+    elif QT_MAJOR == 4:
+        pixmap = QtGui.QPixmap.grabWindow(desktop_id, *x_y_w_h)
+    else:
+        message = "Screen capture not implmented for Qt %d"
+        raise NotImplementedError(message % QT_MAJOR)
+
+    return pixmap
 
 
 # Backwards compatibility, as this used to be a module-level