diff --git a/pandas/core/arrays/_mixins.py b/pandas/core/arrays/_mixins.py
index 11928e79ffc62..22727ac4a4a3d 100644
--- a/pandas/core/arrays/_mixins.py
+++ b/pandas/core/arrays/_mixins.py
@@ -362,7 +362,16 @@ def fillna(self, value, limit: int | None = None, copy: bool = True) -> Self:
                 new_values = self.copy()
             else:
                 new_values = self[:]
-            new_values[mask] = value
+            if self.dtype.kind == "O" and isinstance(value, tuple):
+                # Ensure tuple values are treated as scalars for masked assignment.
+                # Otherwise NumPy may interpret the tuple as a sequence.
+                fill_values = np.empty(
+                    np.asarray(mask, dtype=np.bool_).sum(), dtype=object
+                )
+                fill_values[:] = [value]
+                new_values[mask] = fill_values
+            else:
+                new_values[mask] = value
         else:
             # We validate the fill_value even if there is nothing to fill
             self._validate_setitem_value(value)
diff --git a/pandas/tests/extension/base/missing.py b/pandas/tests/extension/base/missing.py
index 0277bb59bc7f5..7664274fa4375 100644
--- a/pandas/tests/extension/base/missing.py
+++ b/pandas/tests/extension/base/missing.py
@@ -6,6 +6,8 @@
 
 
 class BaseMissingTests:
+    _respects_fillna_copy_false = True
+
     def test_isna(self, data_missing):
         expected = np.array([True, False])
 
@@ -123,18 +125,25 @@ def test_fillna_no_op_returns_copy(self, data):
         tm.assert_extension_array_equal(result, data)
 
     def test_fillna_readonly(self, data_missing):
+        fill_value = data_missing[1]
         data = data_missing.copy()
         data._readonly = True
 
         # by default fillna(copy=True), then this works fine
-        result = data.fillna(data_missing[1])
-        assert result[0] == data_missing[1]
+        res_copy = data.fillna(fill_value, copy=True)
+        assert res_copy[0] == fill_value
         tm.assert_extension_array_equal(data, data_missing)
 
-        # but with copy=False, this raises for EAs that respect the copy keyword
-        with pytest.raises(ValueError, match="Cannot modify read-only array"):
-            data.fillna(data_missing[1], copy=False)
-        tm.assert_extension_array_equal(data, data_missing)
+        if self._respects_fillna_copy_false:
+            with pytest.raises(ValueError, match="Cannot modify read-only array"):
+                data.fillna(fill_value, copy=False)
+            tm.assert_extension_array_equal(data, data_missing)
+        else:
+            # EAs that do not respect the copy keyword, copy=False is ignored
+            res_no_copy = data.fillna(fill_value, copy=False)
+            assert res_no_copy[0] == fill_value
+            tm.assert_extension_array_equal(res_no_copy, res_copy)
+            tm.assert_extension_array_equal(data, data_missing)
 
     def test_fillna_series(self, data_missing):
         fill_value = data_missing[1]
diff --git a/pandas/tests/extension/decimal/test_decimal.py b/pandas/tests/extension/decimal/test_decimal.py
index 5374121a37f63..3ab18c3a7935b 100644
--- a/pandas/tests/extension/decimal/test_decimal.py
+++ b/pandas/tests/extension/decimal/test_decimal.py
@@ -67,6 +67,8 @@ def data_for_grouping():
 
 
 class TestDecimalArray(base.ExtensionTests):
+    _respects_fillna_copy_false = False
+
     def _get_expected_exception(
         self, op_name: str, obj, other
     ) -> type[Exception] | tuple[type[Exception], ...] | None:
diff --git a/pandas/tests/extension/test_arrow.py b/pandas/tests/extension/test_arrow.py
index 3237831ece24d..bf47e52d99171 100644
--- a/pandas/tests/extension/test_arrow.py
+++ b/pandas/tests/extension/test_arrow.py
@@ -271,6 +271,17 @@ def data_for_twos(data):
 
 
 class TestArrowArray(base.ExtensionTests):
+    _respects_fillna_copy_false = False
+
+    def test_fillna_readonly(self, data_missing, monkeypatch):
+        pa_dtype = data_missing.dtype.pyarrow_dtype
+        if pa.types.is_duration(pa_dtype):
+            with monkeypatch.context() as m:
+                m.setattr(self, "_respects_fillna_copy_false", False)
+                super().test_fillna_readonly(data_missing)
+        else:
+            super().test_fillna_readonly(data_missing)
+
     def _construct_for_combine_add(self, left, right):
         dtype = left.dtype
 
@@ -687,21 +698,6 @@ def test_fillna_no_op_returns_copy(self, data):
         assert result is not data
         tm.assert_extension_array_equal(result, data)
 
-    def test_fillna_readonly(self, data_missing):
-        data = data_missing.copy()
-        data._readonly = True
-
-        # by default fillna(copy=True), then this works fine
-        result = data.fillna(data_missing[1])
-        assert result[0] == data_missing[1]
-        tm.assert_extension_array_equal(data, data_missing)
-
-        # fillna(copy=False) is generally not honored by Arrow-backed array,
-        # but always returns new data -> same result as above
-        result = data.fillna(data_missing[1])
-        assert result[0] == data_missing[1]
-        tm.assert_extension_array_equal(data, data_missing)
-
     @pytest.mark.xfail(
         reason="GH 45419: pyarrow.ChunkedArray does not support views", run=False
     )
diff --git a/pandas/tests/extension/test_interval.py b/pandas/tests/extension/test_interval.py
index ada34e7ace680..14c8b7ca252e0 100644
--- a/pandas/tests/extension/test_interval.py
+++ b/pandas/tests/extension/test_interval.py
@@ -79,6 +79,7 @@ def data_for_grouping():
 
 class TestIntervalArray(base.ExtensionTests):
     divmod_exc = TypeError
+    _respects_fillna_copy_false = False
 
     def _supports_reduction(self, ser: pd.Series, op_name: str) -> bool:
         return op_name in ["min", "max"]
diff --git a/pandas/tests/extension/test_numpy.py b/pandas/tests/extension/test_numpy.py
index c3f619e4263df..ba71e5c963de0 100644
--- a/pandas/tests/extension/test_numpy.py
+++ b/pandas/tests/extension/test_numpy.py
@@ -342,11 +342,6 @@ def test_fillna_frame(self, data_missing):
         # Non-scalar "scalar" values.
         super().test_fillna_frame(data_missing)
 
-    @skip_nested
-    def test_fillna_readonly(self, data_missing):
-        # Non-scalar "scalar" values.
-        super().test_fillna_readonly(data_missing)
-
     @skip_nested
     def test_setitem_invalid(self, data, invalid_scalar):
         # object dtype can hold anything, so doesn't raise
diff --git a/pandas/tests/extension/test_sparse.py b/pandas/tests/extension/test_sparse.py
index 4cbbda990b294..3b27e498b1cfa 100644
--- a/pandas/tests/extension/test_sparse.py
+++ b/pandas/tests/extension/test_sparse.py
@@ -97,6 +97,8 @@ def data_for_compare(request):
 
 
 class TestSparseArray(base.ExtensionTests):
+    _respects_fillna_copy_false = False
+
     def _supports_reduction(self, obj, op_name: str) -> bool:
         return True
 
@@ -237,21 +239,6 @@ def test_isna(self, data_missing):
     def test_fillna_no_op_returns_copy(self, data, request):
         super().test_fillna_no_op_returns_copy(data)
 
-    def test_fillna_readonly(self, data_missing):
-        # copy keyword is ignored by SparseArray.fillna
-        # -> copy=True vs False doesn't make a difference
-        data = data_missing.copy()
-        data._readonly = True
-
-        result = data.fillna(data_missing[1])
-        assert result[0] == data_missing[1]
-        tm.assert_extension_array_equal(data, data_missing)
-
-        # fillna(copy=False) is ignored -> so same result as above
-        result = data.fillna(data_missing[1], copy=False)
-        assert result[0] == data_missing[1]
-        tm.assert_extension_array_equal(data, data_missing)
-
     @pytest.mark.xfail(reason="Unsupported")
     def test_fillna_series(self, data_missing):
         # this one looks doable.
diff --git a/pandas/tests/extension/test_string.py b/pandas/tests/extension/test_string.py
index 07c957beef652..1cdc49b2e6930 100644
--- a/pandas/tests/extension/test_string.py
+++ b/pandas/tests/extension/test_string.py
@@ -170,23 +170,14 @@ def test_fillna_no_op_returns_copy(self, data):
         tm.assert_extension_array_equal(result, data)
 
     def test_fillna_readonly(self, data_missing):
-        data = data_missing.copy()
-        data._readonly = True
-
-        # by default fillna(copy=True), then this works fine
-        result = data.fillna(data_missing[1])
-        assert result[0] == data_missing[1]
-        tm.assert_extension_array_equal(data, data_missing)
-
-        # fillna(copy=False) is generally not honored by Arrow-backed array,
-        # but always returns new data -> same result as above
-        if data.dtype.storage == "pyarrow":
-            result = data.fillna(data_missing[1])
-            assert result[0] == data_missing[1]
+        if data_missing.dtype.storage == "pyarrow":
+            # pyarrow-backed strings are immutable, copy=False is ignored,
+            # always returns a new array without raising.
+            self._respects_fillna_copy_false = False
         else:
-            with pytest.raises(ValueError, match="Cannot modify read-only array"):
-                data.fillna(data_missing[1], copy=False)
-        tm.assert_extension_array_equal(data, data_missing)
+            # python-backed strings respect copy=False and raise on read-only.
+            self._respects_fillna_copy_false = True
+        super().test_fillna_readonly(data_missing)
 
     def _get_expected_exception(
         self, op_name: str, obj, other