diff --git a/uv/private/pep517_whl/build_helper.py b/uv/private/pep517_whl/build_helper.py
index a5107788b..bdb232701 100644
--- a/uv/private/pep517_whl/build_helper.py
+++ b/uv/private/pep517_whl/build_helper.py
@@ -48,12 +48,22 @@
 # Get a path to the outdir which will be valid after we cd
 outdir = path.abspath(opts.outdir)
 
-# Resolve CC/CXX to absolute paths so they remain valid after cwd changes
-# into the extracted source tree (Bazel sets these as exec-root-relative).
-for _cc_var in ("CC", "CXX"):
+# Resolve compiler variables to absolute paths so they remain valid after cwd
+# changes into the extracted source tree (Bazel sets these as
+# exec-root-relative).
+for _cc_var in ("CC", "CXX", "SYSROOT"):
     if _cc_var in os.environ and not path.isabs(os.environ[_cc_var]):
         os.environ[_cc_var] = path.abspath(os.environ[_cc_var])
 
+if "SYSROOT" in os.environ:
+    _sysroot = os.environ["SYSROOT"]
+    _sysroot_cflag = f'--sysroot="{_sysroot}"'
+    if "CFLAGS" in os.environ:
+        _cflags = os.environ["CFLAGS"]
+        os.environ["CFLAGS"] = f"{_cflags} {_sysroot_cflag}"
+    else:
+        os.environ["CFLAGS"] = _sysroot_cflag
+
 # Preserve PATH so native sdist builds can find compilers (clang, gcc).
 build_env = dict(os.environ)
 build_env.update({
diff --git a/uv/private/pep517_whl/rule.bzl b/uv/private/pep517_whl/rule.bzl
index 14f1cfcb8..8f041d51c 100644
--- a/uv/private/pep517_whl/rule.bzl
+++ b/uv/private/pep517_whl/rule.bzl
@@ -6,6 +6,8 @@ build backend the sdist declares in its `[build-system]` table.
 """
 
 load("@bazel_tools//tools/cpp:toolchain_utils.bzl", find_cc_toolchain = "find_cpp_toolchain")
+load("@rules_cc//cc:action_names.bzl", "C_COMPILE_ACTION_NAME")
+load("@rules_cc//cc/common:cc_common.bzl", "cc_common")
 load("//py/private/toolchain:types.bzl", "NATIVE_BUILD_TOOLCHAIN", "PY_TOOLCHAIN")
 
 CC_TOOLCHAIN = "@bazel_tools//tools/cpp:toolchain_type"
@@ -70,9 +72,30 @@ def _pep517_native_whl(ctx):
     # rather than falling back to whatever is on the system PATH.
     cc_toolchain = find_cc_toolchain(ctx, mandatory = False)
     if cc_toolchain:
-        env["CC"] = cc_toolchain.compiler_executable
+        feature_configuration = cc_common.configure_features(
+            ctx = ctx,
+            cc_toolchain = cc_toolchain,
+        )
+        c_compiler_path = cc_common.get_tool_for_action(
+            feature_configuration = feature_configuration,
+            action_name = C_COMPILE_ACTION_NAME,
+        )
+
+        # Note that these paths are relative to the bazel exec root,
+        # and they need to be absolutized if they're to be invoked from any
+        # other working directory. (e.g. in build_helper.py for sdist builds.)
+        env["CC"] = c_compiler_path
         extra_inputs.append(cc_toolchain.all_files)
 
+        # We can extract the relative path to the @llvm-provided sysroot from
+        # the list of include directories.
+        # It still needs to be absolutized, so we can't add it directly to
+        # CFLAGS here.
+        for c in cc_toolchain.built_in_include_directories:
+            if c.endswith("sysroot"):
+                env["SYSROOT"] = c
+                break
+
     ctx.actions.run(
         mnemonic = "PySdistNativeBuild",
         progress_message = "Native source compiling {} to a whl".format(archive.basename),