diff --git a/CMakeLists.txt b/CMakeLists.txt
index cf80e37b5..31c95b2c9 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -24,6 +24,7 @@ option(BUILD_SHARED_LIBS "Build shared libraries" ON)
 option(WITH_TENSOR_PARALLEL "Compile with NCCL and MPI backend" OFF)
 option(WITH_FLASH_ATTN "Compile with Flash Attention 2" OFF)
 option(ENABLE_ADDRESS_SANITIZER "ASAN" OFF)
+option(ENABLE_LORA_RUNTIME "Enable experimental runtime LoRA delta injection (W += scale*B@A in-place)" OFF)
 
 MESSAGE(STATUS "Compiler Id: ${CMAKE_CXX_COMPILER_ID}")
 MESSAGE(STATUS "Compiler Version: ${CMAKE_CXX_COMPILER_VERSION}")
@@ -33,6 +34,11 @@ if(ENABLE_PROFILING)
   add_definitions(-DCT2_ENABLE_PROFILING)
 endif()
 
+if(ENABLE_LORA_RUNTIME)
+  message(STATUS "Enable experimental LoRA runtime delta injection")
+  add_definitions(-DCT2_ENABLE_LORA_RUNTIME)
+endif()
+
 if(DEFINED ENV{INTELROOT})
   set(INTEL_ROOT_DEFAULT $ENV{INTELROOT})
 elseif(DEFINED ENV{ONEAPI_ROOT})
diff --git a/include/ctranslate2/models/model.h b/include/ctranslate2/models/model.h
index 6f1d5c760..9a6c33220 100644
--- a/include/ctranslate2/models/model.h
+++ b/include/ctranslate2/models/model.h
@@ -123,6 +123,23 @@ namespace ctranslate2 {
       std::unordered_map<std::string, StorageView> get_variables() const;
       bool layer_exists(std::string prefix) const;
 
+#ifdef CT2_ENABLE_LORA_RUNTIME
+      // Applies a LoRA adapter delta in-place: W' = W + scale * (lora_B @ lora_A).
+      //
+      // This is a low-level primitive — it modifies a single named weight buffer directly.
+      // Adapter pool management, language switching, and revert logic are entirely the
+      // caller's responsibility (see tools/lora_swap/ for a reference implementation).
+      //
+      // Supported dtypes: float32, float16, bfloat16.
+      // int8 and packed weights (CT2_USE_EXPERIMENTAL_PACKED_GEMM) raise std::runtime_error.
+      // NOT thread-safe — caller must hold the inference lock before calling.
+      // Returns false if the variable name is not found (caller may skip silently).
+      bool apply_lora_delta(const std::string& name,
+                            const StorageView& lora_A,  // shape [r, d_in]
+                            const StorageView& lora_B,  // shape [d_out, r]
+                            float scale = 1.0f) const;
+#endif  // CT2_ENABLE_LORA_RUNTIME
+
       // Attributes are saved as scalar variables.
       template <typename T>
       T get_attribute(const std::string& name) const {
diff --git a/python/cpp/whisper.cc b/python/cpp/whisper.cc
index 34500745c..fb3d3e1c9 100644
--- a/python/cpp/whisper.cc
+++ b/python/cpp/whisper.cc
@@ -15,6 +15,22 @@ namespace ctranslate2 {
         return _pool->is_multilingual();
       }
 
+#ifdef CT2_ENABLE_LORA_RUNTIME
+      // Low-level primitive: writes W' = W + scale * (lora_B @ lora_A) into a single
+      // named weight buffer.  Adapter pool management and language switching are the
+      // caller's responsibility.  Acquires the inference lock for the duration of the write.
+      //
+      // Note: only patches replica 0.  For inter_threads > 1, iterate all replicas.
+      bool apply_lora_delta(const std::string& name,
+                            const StorageView& lora_A,
+                            const StorageView& lora_B,
+                            float scale = 1.0f) {
+        std::unique_lock<std::shared_mutex> lock(_mutex);
+        assert_model_is_ready();
+        return const_cast<models::Model&>(*model()).apply_lora_delta(name, lora_A, lora_B, scale);
+      }
+#endif  // CT2_ENABLE_LORA_RUNTIME
+
       size_t n_mels() const {
         return _pool->n_mels();
       }
@@ -341,6 +357,39 @@ namespace ctranslate2 {
                    A list of alignment results.
              )pbdoc")
 
+#ifdef CT2_ENABLE_LORA_RUNTIME
+        .def("apply_lora_delta",
+             &WhisperWrapper::apply_lora_delta,
+             py::arg("name"),
+             py::arg("lora_A"),
+             py::arg("lora_B"),
+             py::arg("scale")=1.0f,
+             R"pbdoc(
+                 [Experimental] Applies a LoRA adapter delta to a single named weight in-place.
+
+                 This is a low-level primitive: it writes W' = W + scale * (lora_B @ lora_A)
+                 directly into the weight buffer and returns immediately.  Adapter pool
+                 management, language switching, and revert logic are entirely the caller's
+                 responsibility.
+
+                 Supported dtypes: float32, float16, bfloat16.
+                 int8 and packed-GEMM weights raise RuntimeError.
+
+                 Note: only the first replica is patched (inter_threads=1 assumed).
+                 For multi-replica deployments, iterate replicas manually.
+
+                 Arguments:
+                   name:   CT2 variable name, e.g.
+                           ``"decoder/layer_0/self_attention/linear_0/weight"``
+                   lora_A: StorageView of shape [r, d_in]  (the A matrix).
+                   lora_B: StorageView of shape [d_out, r] (the B matrix).
+                   scale:  Scalar multiplier (alpha/r in standard LoRA notation).
+
+                 Returns:
+                   True if the variable was found and updated; False otherwise.
+             )pbdoc")
+#endif  // CT2_ENABLE_LORA_RUNTIME
+
         .def("unload_model", &WhisperWrapper::unload_model,
              py::arg("to_cpu")=false,
              py::call_guard<py::gil_scoped_release>(),
diff --git a/src/models/model.cc b/src/models/model.cc
index 1d8295b0a..209b8fb24 100644
--- a/src/models/model.cc
+++ b/src/models/model.cc
@@ -264,6 +264,48 @@ namespace ctranslate2 {
       return false;
     }
 
+#ifdef CT2_ENABLE_LORA_RUNTIME
+    bool Model::apply_lora_delta(const std::string& name,
+                                 const StorageView& lora_A,
+                                 const StorageView& lora_B,
+                                 float scale) const {
+      // Look up variable. Packed weights require unpack+repack, not yet supported.
+      auto it = _variable_index.find(name);
+      if (it == _variable_index.end()) {
+        const std::string packed_name = name + "_packed";
+        it = _variable_index.find(packed_name);
+        if (it == _variable_index.end())
+          return false;
+        throw std::runtime_error(
+          "apply_lora_delta: packed weights are not supported (name=" + name
+          + "). Rebuild without CT2_USE_EXPERIMENTAL_PACKED_GEMM.");
+      }
+
+      StorageView& weight = *it->second;
+      const DataType orig_dtype = weight.dtype();
+      const Device compute_dev = weight.device();
+
+      if (orig_dtype == DataType::INT8)
+        throw std::runtime_error(
+          "apply_lora_delta: int8 quantized weights are not supported; "
+          "use compute_type=float32 or float16.");
+
+      // Cast LoRA matrices to float32 on weight's device.
+      StorageView A_f32 = lora_A.to(DataType::FLOAT32).to(compute_dev);
+      StorageView B_f32 = lora_B.to(DataType::FLOAT32).to(compute_dev);
+
+      // Cast weight to float32, run fused GEMM, write back.
+      // W_f32 = scale * B @ A + 1.0 * W_f32  (single cuBLAS SGEMM on GPU).
+      StorageView W_f32 = weight.to(DataType::FLOAT32);
+      const ops::Gemm gemm_op(/*alpha=*/scale, /*beta=*/1.0f,
+                               /*trans_a=*/false, /*trans_b=*/false);
+      gemm_op(B_f32, A_f32, W_f32);
+
+      weight = W_f32.to(orig_dtype);
+      return true;
+    }
+#endif  // CT2_ENABLE_LORA_RUNTIME
+
     bool Model::get_flag_with_default(const std::string& name, bool default_value) const {
       return get_attribute_with_default(name, static_cast<int8_t>(default_value));
     }